Martin Maier,Muthusamy Jayaraman,Akin Akinc,Shigeo Matsuda,Pachamuthu Kandasamy,Kallanthottathil G. Rajeev,Muthiah Manoharan
申请号：
US16520183
公开号：
US20190374646A1
申请日:
2019.07.23
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.
