Muthiah MANOHARAN,Martin Maier,Muthusamy Jayaraman,Shigeo Matsuda,Narayanannair K. Jayaprakash,Kallanthottathil G. Rajeev,Akin Akinc,Thomas A. Baillie
申请号：
US13153200
公开号：
US20120027803A1
申请日:
2011.06.03
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.
