(BENZO[D]THIAZOL-2-YLCARBAMOYL) 1,2,3,4-TETRAHYDROQUINOLINES(HETERO)ARYLSUBSTITUE ET COMPOSES ASSOCIES ET LEURS UTILISATIONS POUR LE TRAITEMENT DU CANCER ET D'UN EXCES DE PLAQUETTES
ABBOTT LABORATORIES;GENENTECH, INC.;THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH
发明人:
BAELL, JONATHAN BAYLDON,BUI, CHINH THIEN,COLMAN, PETER,DUDLEY, DANETTE A.,FAIRBROTHER, WAYNE J.,FLYGARE, JOHN A.,LESSENE, GUILLAUME LAURENT,NDUBAKU, CHUDI,NIKOLAKOPOULOS, GEORGE,RYE, CARL STEVEN,SLEEB
申请号：
CA2747161
公开号：
CA2747161C
申请日:
2009.12.17
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
In one aspect, the present invention provides for a compound of Formula (I) inwhich, the variables X1, X2a,' X2b,X2c, R1, B, L, E, A and the subscript n are as defined herein. In anotheraspect, the present invention provides for pharmaceuticalcompositions comprising compounds of Formula (I) as well as methods for usingcompounds of Formula (I) for the treatment ofdiseases and conditions (e.g., cancer, thrombocythemia, etc) characterized bythe expression or over-expression of Bc1-2anti-apoptotic proteins, e.g., of anti-apoptotic Bc1-x L proteins.
