ABBOTT LABORATORIES;GENENTECH INC;THE WALTER AND ELIZA HALL INSTUTITE OF MEDICAL RESEARCH
发明人:
BAELL JONATHAN BAYLDON,BUI CHINH THIEN,COLMAN PETER,DUDLEY DANETTE ANDREA,FAIRBROTHER WAYNE J,FLYGARE JOHN A,LESSENE GUILLAUME LAURENT,NDUBAKU CHUDI,NIKOLAKOPOULOS GEORGE,RYE CARL STEVEN,SLEEBS BRAD E
申请号：
ZA201104463
公开号：
ZA201104463B
申请日:
2011.06.15
申请国别(地区):
ZA
年份:
2012
代理人:
摘要：
In one aspect, the present invention provides for a compound of Formula I in which in Formula I, the variables X1, X2a, X2b, X2c, R1, B, L, E, A and the subscript n are as defined herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.
