COMPOSÉS ET MÉTHODES D'UTILISATION

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专利权人:

ABBOTT LABORATORIES;GENENTECH, INC.; INC.;THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH;GENENTECH

发明人:

BAELL, JONATHAN, BAYLDON,BUI, CHINH, THIEN,COLMAN, PETER,DUDLEY, DANETTE, A.,FAIRBROTHER, WAYNE, J.,FLYGARE, JOHN, A.,LESSENE, GUILLAUME, LAURENT,NDUBAKU, CHUDI,NIKOLAKOPOULOS, GEORGE,RYE, CARL, STEVE

申请号：

EP09837907

公开号：

EP2376085A4

申请日:

2009.12.17

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

In one aspect, the present invention provides for a compound of Formula I in which in Formula I, the variables X1, X2a, X2b, X2c, R1, B, L, E, A and the subscript n are as defined herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/