Peter Colman;Brad Edmund Sle;John A. Flygare;Chudi Ndubaku;Chinh Thien Bui;Guillaume Laurent Lessene;Danette A. Dudley;George Nikolakopoulos;Wayne J. Fairbrother;Jonathan Bayldon Baell;Carl Steven Rye
发明人:
Jonathan Bayldon Baell,Chinh Thien Bui,Peter Colman,Danette A. Dudley,Wayne J. Fairbrother,John A. Flygare,Guillaume Laurent Lessene,Chudi Ndubaku,George Nikolakopoulos,Carl Steven Rye,Brad Edmund Sle
申请号：
US12641063
公开号：
US08114893B2
申请日:
2009.12.17
申请国别(地区):
US
年份:
2012
代理人:
摘要：
In one aspect, the present invention provides for a compound of Formula Iin which in Formula I, the variables X1, X2a, X2b, X2c, R1, B, L, E, A and the subscript n are as defined herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.
