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Amine polymers for use as bile acid sequestrants
专利权人:
Relypsa; Inc.
发明人:
CONNOR, Eric,BIYANI, Kalpesh,HECKER, Scott,LEES, Inez,MANSKY, Paul,MU, YongQi,SALAYMEH, Felah,ZHANG, Hongmin,BERGBREITER, David,QUAKER, Grace,COPE, Michael James,GOKA, Elizabeth,LEE, Angela,MADSEN, De
申请号:
ES11706453
公开号:
ES2661079T3
申请日:
2011.02.24
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
An amine polymer comprising repeat units derived from the polymerization of an amine monomer in a cross-linking monomer, wherein the amine monomer is an amine of formula 2 having the structure: ** (See formula) ** wherein each R2 is independently C2 to C8 alkylene or C2 to C8 alkylene in which one or more of the CH2 groups of the alkylene group is substituted with at least one amide functional group, and R3 is C2 to C12 alkylene, arylene, diformylheterocycle, or C2 to C8 alkylene in which one or more of the -CH2 groups of the alkylene group is substituted with an amide, carbonyl, ether, ester, cycloalkyl, aryl or heterocycle functional group; and the crosslinking monomer is guanidine, a guanidinium salt, a compound having the formula X-R1-X or a combination thereof, wherein each X is independently a leaving group, R1 is C8 to C6 alkylene or alkylene C5 to C50 in which one or more of the -CH2 groups of the alkylene group is substituted with an amide, carbonyl, ether, ester, cycloalkyl, aryl or heterocycle functional group, or one or more of the -CH2- groups of the alkylene group it is substituted with hydroxy; and in which at least one of R1 or R3 is a hydrophobic group having a calculated log P (c Log P) greater than 4.Un polímero de amina que comprende unidades de repetición derivadas de la polimerización de un monómero de amina en un monómero de reticulación, en el que el monómero de amina es una amina de fórmula 2 que tiene la estructura: **(Ver fórmula)** en la que cada R2 es independientemente alquileno C2 a C8 o alquileno C2 a C8 en el que uno o más de los grupos - CH2 del grupo alquileno está sustituido con al menos un grupo funcional amida, y R3 es alquileno C2 a C12, arileno, diformilheterociclo, o alquileno C2 a C8 en el que uno o más de los grupos -CH2 del grupo alquileno está sustituido con un grupo funcional amida, carbonilo, éter, éster, cicloalquilo, arilo o heterociclo; y el monómero de reticulación es guanidina, una sal de guanidinio, un compuesto q
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