8-anthrax-2 - (2,3-pyr-6-ilo Di substitution) - 1,2,3,4-tetrahydroisomer phenyl ether derivatives as pathogenic inducers for the treatment of cancer and immune and autoimmune diseases
It refers to the preparation of 8-carbohydrate-2 - (2,3-pirid-6-ilo District) - 1,2,3,4-tetrahydroisophenyl ether (I), where x is the substitute for isomerization； Y1 is phenyl or isomerized (C5-C6), which can be optionally combined into one or two rings； L1 is (cr6r7) Q (cr6r7) S-O (cr6r7) r, wherein R6 and NH2 are R7, respectively, NHC (o) NH2, among others； q is 1-3； s and R are 0-3； Y2 is cyclopentadiene (C8-C14),Isopropyl propyl (C8-C14),Among other things, Z1 is halogen, NO2, CN, etc.； R1 is halogen, tar (C1-C6),R2 is halo, alquenilo (C2-C6), among other things,Among other things, R3 is halogen, tar (C1-C6),Blue Nile (C2-C6),Among others, M is 0-3； n is 0-6； P is 0-2. , 3-1]]] - 1,3 - [1,3]]] - 3 - [1,3 - [1,3]]]]]]]]]]]]] 2. Dimethyl-1 - (tricycle [3.3.1.13], (7) Dec-1-ilmer-1h-pirazol-4-il] piridin-2-carboxilico, etc. He also mentioned a pharmaceutical composer These compounds inhibit the activity of Bcl-xL anti necrosis protein and can be used to treat bladder cancer, lymphocytic leukemia and poliomyelitis.SE REFIERE A COMPUESTOS DERIVADOS DE 8-CARBAMOIL-2-(2,3-PIRID-6-ILO DISUSTITUIDO)-1,2,3,4-TETRAHIDROISOQUINOLINA DE FORMULA (I) DONDE X ES HETEROARILO OPCIONALMENTE SUSTITUIDO； Y1 ES FENILENO O HETEROARILENO(C5-C6) OPCIONALMENTE FUSIONADO A UNO O DOS ANILLOS； L1 ES (CR6R7)q, (CR6R7)s-O-(CR6R7)r, ENTRE OTROS, EN DONDE R6 Y R7 SON CADA UNO H, NH2, NHC(O)NH2, ENTRE OTROS； q ES DE 1 A 3； s Y r SON CADA UNO DE 0 A 3； Y2 ES CICLOALQUILO(C8-C14), HETEROCICLOALQUILO(C8-C14), ENTRE OTROS； Z1 ES HALOGENO, NO2, CN, ENTRE OTROS； R1 ES HALO, ALQUILO(C1-C6), ENTRE OTROS； R2 ES HALO, ALQUENILO(C2-C6), ENTRE OTROS； R3 ES HALO, ALQUILO(C1-C6), ALQUINILO(C2-C6), ENTRE OTROS； m ES DE 0 A 3； n ES DE 0 A 6； p ES DE 0 A 2. SON COMPUESTOS PREFERIDOS: ACIDO 6-[8-(1,3-BENZOTIAZOL-2-ILCARBAMOIL)-3,4-DIHIDROISOQUINOLIN-2(1H)-IL]-3-{1-[TRICICLO[3.3.1.13,7]DEC-1-ILMETIL]-1H-PIRAZOL-4-IL}PIRIDIN-2-CARBOXILICO； ACIDO 6-[8-(1,3-BENZOTIAZOL-2-ILCARBAMOIL)-3,4-DIHIDROISOQUINOLIN-2(1H)-I
