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Pyrazine Derivatives of GPR40 agonists for the treatment of Type II diabetes
专利权人:
JANSSEN PHARMACEUTICA N.V.
发明人:
申请号:
ARP150102181
公开号:
AR101132A1
申请日:
2015.07.08
申请国别(地区):
AR
年份:
2016
代理人:
摘要:
1. Claim 1: a formula compound (1) marked by R1 selected from the groups of phenyl, pyridine-4-ilo and sulfur fluorine; marked by that R1 can be independently replaced by one or two c83218c24j substitutes;e. Methoxi, fluoro, Ciano, O trifluorometyl; provided that R1 phenyl was replaced by no more than one methoxi substitute; g was selected from c832131 asphalt group;C₁₋₆ alkoxy;C₃₋₇ cycloalkyl;2,2,6,6-tetramethyltetrahydro-2H-pyran-4-yloxy; oxetan-3-yloxy; C₂₋₆-1-en-1-yl; 3,3,3-trifluoropropyloxy; 1,1,1-trifluoroprop-2-yl; (C₁₋₆ alkyl) thiophene-2-yl; phenyl optionally substituted with one to two C₁₋₄ alkyl substituents;(C₁₋₆ alkyl) amino; di (C₁₋₆ alkyl) amino; heterocyclyl wherein said heterocyclyl is attached to the ring of the pyrazine nucleus through a nitrogen atom and said heterocyclyl is optionally spiked to a C₃₋₇ cycloalkyl group;1. Equation ring (2);C₃₋₇ cycloalkyloxy;e. C83323qul c833318327e metoxi, including c833318327c and c833318327c parts;of the C₃₋₇ cycloalkyl-methoxy are optionally substituted with one to four methyl substituents; R² is C₃₋₅ cycloalkyl,1. Lease land No. c833218331 and 832626;Or cyanide, or a pygmy isomer, the troposphere, or a salt that's medically acceptable.Reivindicación 1: Un compuesto de fórmula (1) caracterizado porque R¹ se selecciona del grupo que consiste en fenilo, piridin-4-ilo, y tiofenilo; caracterizado porque R¹ está opcionalmente sustituido independientemente con uno o dos sustituyentes que son alquilo C₁₋₄, metoxi, fluoro, ciano, o trifluorometilo; siempre y cuando el fenilo de R¹ está sustituido con no más de un sustituyente metoxi; G se selecciona del grupo que consiste en alquilo C₁₋₆; alcoxi C₁₋₆; cicloalquilo C₃₋₇; 2,2,6,6-tetrametiltetrahidro-2H-piran-4-iloxi; oxetan-3-iloxi; alq C₂₋₆-1-en-1-ilo; 3,3,3-trifluoropropiloxi; 1,1,1-trifluoroprop-2-ilo; (alquil C₁₋₆)tiofen-2-ilo; fenilo opcionalmente sustituido con uno a dos sustituyentes alquilo C₁₋₄; (alquil C₁₋₆)amino; di(alquil C₁₋₆)amino; heterociclilo donde d
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