The present invention relates to small compounds that modulate the expression of and/or function of sodium channel, voltage-gated, alpha subunit (SCNxA). The invention also relates to pharmaceutical compositions containing such small molecules and their use in treating diseases and disorders associated with the expression of SCNxA.本發明係關於調節電壓門控鈉離子通道α次單元(SCNxA)之表現及/或功能之小化合物。本發明亦係關於含有該等小分子之醫藥組合物及其在治療與SCNxA表現相關之疾病及病症中的用途。