The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.本發明部分地係關於稠合雜芳基化合物及組合物，其可用於預防及/或治療與電壓閘控鈉離子通道之異常功能(例如異常晚/持續性鈉電流)有關之疾病或病況。本文亦提供治療與鈉離子通道之異常功能有關之疾病或病況的方法，該疾病或病況包括神經病症(例如德拉韋症候群(Dravet syndrome)、癲癇)、疼痛及神經肌肉病症。
