The present invention relates to substituted aromatic compounds of Formula I and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds in the prevention and/or treatment of various diseases and conditions in subjects, including the prevention or treatment of (i) blood disorders, (ii) renal disorders, a nephropathies, or renal disorder complications; (iii) inflammatory-related diseases; and/or (iv) oxidative stress related disorders.本發明涉及式I的取代的芳族化合物及其藥物用途。本發明的特別方面涉及這些化合物在預防和/或治療受治療者的多種疾病和病症,包括預防或治療(i)血液疾患;(ii)腎功能異常、腎病或腎功能異常併發症;(iii)炎性相關疾病;和/或(iv)氧化壓力相關疾患中的用途。