ULRICH DR. BOTHE,OLIVER MARTIN DR. FISCHER,MATTHIAS DR. BUSEMANN,NAOMI DR. BARAK,ANDREA DR. ROTGERI,TOBIAS DR. MARQUARDT
申请号：
ARP140100555
公开号：
AR094852A1
申请日:
2014.02.21
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Akr1c3 inhibitors of formula (1) and to processes for their preparation, production of useful drugs for the prophylaxis and / or treatment of diseases, including disorders of bleeding and endometriosis.Claim 1: compounds of the General formula (1) where X is independently where Carbon Carbon or nitrogen can be substituted with r u00b9； and carbon or nitrogen, carbon can be replaced with R u00b2 r u00b9 R u00b2； and each is independently Hydrogen, Hal u00f3geno c u2081 u208b u2086 alquenilo c u2082 u208b u2086, alkyl, cycloalkyl, alquinilo c u2082 u208b u2086, c u2083 u208b u2086 c u2081 u208b u2086, alkoxy, haloalquilo c u2081 u208b u2086,Haloalcoxi c u2081 u208b u2086, Nitrile, Nitro, so u2082ch u2083 so u2082ch u2082ch u2083 -, -, - (c = o) ch u2083, carboxyl, hydroxyl, nh u2082 ch u2082nh u2082 -, -, - ch u2082oh, CH (OH) ch u2083 (ch u2083) u2082oh, - C, - (c = o) nh u2082, - (c = o) nhch u2083, - (c = o) nhch u2082ch u2083, - (c = o) n (ch u2083) u2082 so u2082nh u2082 so u2082nhch u2083 -, -, - so u2082n (ch u2083 u2082 is Hydrogen or r u00b3)； R u2074 is Hydrogen, halogen, alkyl or cycloalkyl c u2081 u208b u2086, c u2083 u208b u2086 cicloalquil c u2083 u208b u2086 alkyl c u2081 u208b u2086,With up to 6 which are optionally substituted Halogen Atoms and optionally imidazols disubstituted with hydroxyl or alkoxy, c u2081 u208b u2086, haloalcoxi c u2081 u208b u2086； r u2075 c u2081 u208b u2086 is Hydrogen, alkyl or cycloalkyl alkyl and cycloalkyl c u2083 u208b u2086, where c u2081 u208b u2086 c u2083 u208b u2086 With up to 6 are optionally substituted Halogen Atoms and optionally imidazols or disubstituted with hydroxylC u2081 u208b u2086 Hydroxy alkyl, alkoxy c u2081 u208b u2086 c u2081 u208b u2086 alkyl, Hydroxy, alkoxy c u2082 u208b u2086, haloalcoxi c u2081 u208b u2086 c u2083 u208b u2086, cycloalkyl, aryl, heteroaryl, heterocicloalquilo 3 - 10 members c u2081 u208b u2086 alkyl, aryl, heteroaryl c u2081 u208b u2086 alkyl, - C (= o) R - C (= o) - C (= o
