This Hair Ming Department Off Yu mono- Seed compound of formula IWherein low-carbon Number alkyl or benzyl that R1 As Hydrogen, Visual need The Halogen elements or low-carbon Number alkoxies to replaceR2 As Hydrogen, Halogen elements or OR, the low-carbon Number alkyl that wherein R As low-carbons Number alkyl, aryl Huo The Halogen elements replaceR3 As Hydrogen or fluorineAr As phenylN As 0 or 1O As 0,1 or 2Qi Medical Drug Huo Which of Ji. The micro An Knot conjunctions Shou Body (TAARs) of Yi Hair Now compound of formula I Right With, especially TAAR1 have good Pro and power. The compounds can control Treatment suppressions Yu with what, coke Account barriers Hinder, hot-tempered Yu diseases, attention lack sunken Over Move barriers Hinder (ADHD), the disease Like of With Pressure power phases Off, essence mind hinder Hinder such as:Schizophrenia, mind The diseases, such asParkinsons disease, mind The degenerative diseases, such as:Ah Hereby sea Mos disease, Epilepsy Epilepsy disease, Pian Head pains, high blood Pressure, Drug Wu Abuse Ji Dai Xie Shi Tone, such as:Drink eat Iso often, diabetes, diabetes And Hair diseases, obesity, blood lipid Iso often, Neng amount Xiao Hao With assimilations Shi Tone, Body Warm Body inner equilibrium Shi Tone and Gong Neng Shi Tone, sleep and Day nights Festival Lv Shi Tone and angiocarpy Zhang Hinder.本發明係關於一種式I化合物其中R1 為氫、視需要經鹵素或低碳數烷氧基取代的低碳數烷基或苯甲基;R2 為氫、鹵素或OR,其中R為低碳數烷基、芳基或經鹵素取代的低碳數烷基;R3 為氫或氟;Ar 為苯基;n 為0或1;o 為0、1或2;及其醫藥活性鹽。已發現式I化合物對與微量胺結合之受體(TAARs),尤其TAAR1,具有良好之親和力。該化合物可用於治療抑鬱、焦慮性障礙、躁鬱症、注意力缺陷過動障礙(ADHD)、與壓力相關的症狀、精神障礙如:精神分裂症、神經疾病,如;帕金森氏病、神經退化疾病,如:阿茲海默氏病、癲癇症、偏頭痛、高血壓、藥物濫用及代謝失調,如:飲食異常、糖尿病、糖尿病併發症、肥胖、血脂異常、能量消耗與同化作用失調、體溫體内平衡失調及功能失調、睡眠及晝夜節律失調、及心血管障礙。
