As for this invention, the method of dealing with the bleeding characteristic obstacle in the suffering body with the dosage of manufacturing ones where IXa factor is concentrated is offered, this method includes the process which prescribes pharmacy manufacturing ones which 10% IXa factor (mg/entire protein mg) are included at least. It rearranges IXa factor and, it can be produced by activating the IXth factor which is produced by technology with proteolysis. In addition as for this invention, it offers the method in order to produce IXa factor from blood plasma fraction, this method does not contain purekarikuren activity almost, or brings the IXa factor product which is not contained completely.本発明は、第IXa因子が濃縮された調製物の投与によって被験体における出血性障害を処置する方法を提供し、この方法は、少なくとも10%の第IXa因子(mg/総タンパク質mg)を含む薬学的調製物を投与する工程を包含する。第IXa因子は、組み換え技術により産生された第IX因子をタンパク質分解によって活性化することによって産生され得る。本発明はまた、血漿画分から第IXa因子を産生するための方法を提供し、この方法は、プレカリクレン活性をほとんど含有しないかまたは全く含有しない第IXa因子産物をもたらす。
