#$%^&*AU2020101264A420200820.pdf#####ABSTRACT The present invention provides a method for optimizing a radix Aconiti lateralis processing method, relating to the technical field of traditional Chinese medicine processing. The method 5 for optimizing a radix Aconiti lateralis processing method includes carrying out experimental design on to-be-optimized factors through a Box-Behenken design method to obtain processed products with different factors and different parameters; performing liquid chromatography-mass spectrometry detection on the processed products to obtain respective fingerprints; after common peaks of the fingerprints are screened, analyzing main causes of 10 areas of the common peaks to construct a comprehensive evaluation function of processed radix Aconiti lateralis products; calculating a score of a comprehensive evaluation function of each group according to the function, constructing an equation between the to-be-optimized factors and the score, and predicting an optimal process parameter according to the equation. The method for optimizing a radix Aconiti lateralis processing method provided by the present 15 invention is suitable for optimizing factors in various processing methods, has wide universality and is easy to operate. 20 25 30 35 40