The present invention provides antibodies etc. that have the inhibiting activity of the cell cancerization and/or tumor cell proliferation.The present invention provides anti-EPHA2 antibodies or functional fragments of the antibodies, which comprise a humanized heavy chain derived from the anti-EPHA2 antibody SH348-1 produced by hybridoma SH348-1 (FERM BP-10836) and a humanized light chain derived from the anti-EPHA2 antibody SH357-1 produced by hybridoma SH357-1(FERM BP-10837) medicine containing the antibodies as active ingredients etc.本發明係提供一種具有抑制細胞癌化及/或腫瘤細胞增殖活性的抗體等。本發明提供一種抗EPHA2抗體或該抗體之機能性片段,其係包含:源自於融合瘤SH348-1(FERM BP-10836)所產生之抗EPHA2抗體SH348-1之人化重鏈及源自於融合瘤SH357-1(FERM BP-10837)所產生之抗EPHA2抗體SH357-1之人化輕鏈而成;及含有以該抗體作為有效成分之醫藥等。
