[subject]The present invention relates the antibody etc. that have the inhibiting activity of the cell cancerization and/or tumor cell proliferation.[solution]The present invention provides the antibody which recognizes the epitope recognized with the antibody produced by hybridoma SH348-1(FERM BP-10836) or hybridoma SH357-1(FERM BP-10837), the antibody produced by hybridoma SH348-1 or hybridoma SH357-1, the antibody that humanirizes from the antibody produced by hybridoma SH348-1 or hybridoma SH357-1, and the medicine contains the antibody as the active ingredient etc.提供具有細胞之癌化及/或腫瘤細胞增殖抑制活性之抗體等。提供認識由融合瘤SH348-1(FERM BP-10836)或融合瘤SH357-1(FERM BP-10837)產生之抗體來認識之抗原決定部位之抗體、融合瘤SH348-1或融合瘤SH357-1所產生之抗體,將融合瘤SH348-1或融合瘤SH357-1所產生之抗體予以人化之抗體,以該抗體為有效成分含有之醫藥等。
