APOPTOTIC ANTI- IGE ANTIBODIES BINDING THE MEMBRANE-BOUND IGE

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专利权人:

INC.;GENENTECH

发明人:

WU, LAWREN,BALAZS, MERCEDESZ,BRIGHTBILL, HANS,CHAN, ANDREW,CHEN, YVONNE,CHUNTHARAPAI, ANAN,DENNIS, MARK,WONG, TERENCE

申请号：

NZ58055308

公开号：

NZ580553A

申请日:

2008.03.21

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Provided is an anti-IgE/M1' antibody that specifically binds an epitope in the M1' segment of IgE defined by residues 317 to 352 of SEQ ID NO:1 and which induces apoptosis in IgE-expressing B-cells. Further provided are deposited murine hybridomas expressing such antibodies, methods of antibody production and use of the antibodies against IgE mediated disorders, including allergies, asthma and IgE myeloma.

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