Disclosed are: an antibody capable of inhibiting the canceration of a cell and/orthe proliferation of a tumor cell; and others. Specifically disclosed are: anantibody which can recognize an epitope that can be recognized by an antibodyproduced by a hybridoma SH 348-1 (FERM BP-10836) or a hybridoma SH 357-1 (FERMBP-10837); an antibody produced by a hybridoma SH 348-1 or a hybridoma SH 357-1;an antibody which is produced by humanizing an antibody produced by a hybridomaSH 348-1 or a hybridoma SH 357-1; a pharmaceutical agent comprising any one ofthe aforementioned antibodies as an active ingredient; and others.