MAO, WEIGUANG,JUNUTULA, JAGATH, REDDY,POLAKIS, PAUL
申请号：
NZ58451408
公开号：
NZ584514A
申请日:
2008.10.16
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Cysteine engineered anti-TENB2 antibodies are engineered by replacing one or more amino acids of a parent anti-TKNB2 antibody with non cross-linked, reactive cysteine amino acids. Methods of design, preparation, screening, and selection of the cysteine engineered anti-TENB2 antibodies are provided. Cysteine engineered anti-TENB2 antibodies (Ab) are conjugated with one or more drug moieties (D) through a linker (L) to form cysteine engineered anti-TENB2 antibody-drug conjugates having Formula I: Ab-(L-D)p I where p is 1 to 4. Diagnostic and therapeutic uses for cysteine engineered antibody drug compounds and compositions are disclosed.
