Cysteine engineered anti-MUC16 antibodies and antibody drug conjugates

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专利权人:

INC.;GENENTECH

发明人:

Mallet, William,Junutula, Jagath R.

申请号：

AU2008251608

公开号：

AU2008251608B2

申请日:

2008.05.07

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

Cysteine engineered anti-MUC16 antibodies are engineered by replacing oneor more amino acids of a parent anti-MUC16 antibody with non cross-linked, reactivecysteine amino acids. Methods of design, preparation, screening, and selectionof the cysteine engineered anti-MUC16 antibodies are provided. Cysteine engineeredanti-MUC16 antibodies (Ab) are conjugated with one or more drug moieties (D)through a linker (L) to form cysteine engineered anti-MUC16 antibody-drug conjugateshaving Formula I: Ab- (L- D)

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/