MAO, Weiguang,JUNUTULA, Jagath Reddy,POLAKIS, Paul
申请号：
AU2014203779
公开号：
AU2014203779A1
申请日:
2014.07.10
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
#$%^&*AU2014203779A120140731.pdf#####ABSTRACT Cysteine engineered anti-TENB2 antibodies are engineered by replacing one or more amino acids of a parent anti-TENB2 antibody with non cross-linked, reactive cysteine 5 amino acids. Methods of design, preparation, screening, and selection of the cysteine engineered anti-TENB2 antibodies are provided. Cysteine engineered anti-TENB2 antibodies (Ab) are conjugated with one or more drug moieties (D) through a linker (L) to form cysteine engineered anti-TENB2 antibody-drug conjugates having Formula 1: Ab-(L-D)p I 10 where p is 1 to 4. Diagnostic and therapeutic uses for cysteine engineered antibody drug compounds and compositions are disclosed. 5553774_1 (GHMatters) P83470.AU.1
