Junutula, Jagath Reddy,Mao, Weiguang,Polakis, Paul
申请号：
AU2008312457
公开号：
AU2008312457B2
申请日:
2008.10.16
申请国别(地区):
AU
年份:
2014
代理人:
摘要：
Cysteine engineered anti-TENB2 antibodies are engineered by replacing oneor more amino acids of a parent anti-TKNB2 antibody with non cross-linked, reactivecysteine amino acids. Methods of design, preparation, screening, and selectionof the cysteine engineered anti-TENB2 antibodies are provided. Cysteine engineeredanti-TENB2 antibodies (Ab) are conjugated with one or more drug moieties (D)through a linker (L) to form cysteine engineered anti-TENB2 antibody-drug conjugateshaving Formula I: Ab-(L-D)
