MÉTHODE DE TRAITEMENT DE MALADIES AUTO-IMMUNES À L'AIDE DE CELLULES T CD4 MODIFIÉES EN VUE D'OBTENIR UNE STABILISATION DE L'EXPRESSION DU GÈNE FOXP3 ENDOGÈNE
Seattle Children's Hospital (DBA Seattle Children's Research Institute)
发明人:
SCHARENBERG, Andrew M.,RAWLINGS, David J.,TORGERSON, Troy
申请号：
EP16920361
公开号：
EP3532105A4
申请日:
2016.10.31
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Disclosed are methods of making a genetically cell that expressed FOXP3 and methods of treatment. In some embodiments, the method can providing a first nucleotide sequence, wherein the first nucleotide sequence comprises a coding strand, the coding strand comprising one or more regulatory elements and a FOXP3 gene or portion thereof providing a nuclease and performing a gene editing process on the first nucleotide sequence, which edits said one or more regulatory elements, and optionally edits the FOXP3 gene or portion thereof. Methods of treating a subject suffering from an autoimmune disease and subjects suffering the effects of organ transplantation are also provided.
