Seattle Children's Hospital (dba Seattle Children's Research Institute)
发明人:
Andrew M. Scharenberg,David J. Rawlings,Troy Torgerson
申请号：
US16345622
公开号：
US20190247443A1
申请日:
2016.10.31
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Disclosed are methods of making a genetically cell that expressed FOXP3 and methods of treatment. In some embodiments, the method can providing a first nucleotide sequence, wherein the first nucleotide sequence comprises a coding strand, the coding strand comprising one or more regulatory elements and a FOXP3 gene or portion thereof providing a nuclease and performing a gene editing process on the first nucleotide sequence, which edits said one or more regulatory elements, and optionally edits the FOXP3 gene or portion thereof. Methods of treating a subject suffering from an autoimmune disease and subjects suffering the effects of organ transplantation are also provided.
