PROBLEM TO BE SOLVED: To provide delayed-release pharmaceutical formulations that impart a delay of release after the drug is administered to a patient and then rapidly release the drug.SOLUTION: The delayed-release pharmaceutical formulation is produced by formulating a drug together with a disintegrant such as a low-substituted hydroxypropyl cellulose and a microcrystalline cellulose which is a spheroidizing promoter to form a core, and by coating the core with a regulatory membrane made of a water-soluble gel-forming polymer, such as hydroxylpropylmethyl cellulose or methyl cellulose and a water-insoluble film-forming polymer such as an alkyl cellulose.COPYRIGHT: (C)2010,JPO&INPIT【課題】患者に投与してから薬剤放出を遅延させた後、薬剤を迅速に放出する遅延放出医薬製剤の提供。【解決手段】低置換のヒドロキシプロピルセルロースなどの崩壊剤と、球状体化促進剤である微結晶セルロースと共に薬剤を製剤して核を生成し、前記核をヒドロキシプロピルメチルセルロースまたはメチルセルロースなどの水溶性のゲルを形成する重合体及びアルキルセルロースなどの非水溶性のフィルムを形成する重合体からなる調節膜でコーティングした遅延放出医薬製剤。【選択図】図2
