The Board of Trustees of the Leland Stanford Junior University
发明人:
Weissman, Irving L.,McKenna, Kelly Marie,Willingham, Stephen,Ho, Doris Po Yi,Dalerba, Piero D.,Volkmer, Jens-Peter
申请号：
AU2016365829
公开号：
AU2016365829A1
申请日:
2016.12.08
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
Methods are provided for targeting cells for depletion, including without limitation cancer cells, in a regimen comprising contacting the targeted cells with a combination of agents, including (i) an agent that blockades CD47 activity； and (ii) an antibody that specifically binds to EGFR. In some embodiments the cancer cells have a mutated form of one or more of KRAS, NRAS or BRAF. The level of depletion of the targeted cell is enhanced relative to a regimen in which a single agent is used； and the effect may be synergistic relative to a regimen in which a single agent is used.
