THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人:
WEISSMAN, IRVING L.,MCKENNA, KELLY MARIE,WILLINGHAM, STEPHEN,HO, DORIS PO YI,DALERBA, PIERO D.,VOLKMER, JENS-PETER
申请号：
CA3005911
公开号：
CA3005911A1
申请日:
2016.12.08
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Methods are provided for targeting cells for depletion, including without limitation cancer cells, in a regimen comprising contacting the targeted cells with a combination of agents, including (i) an agent that blockades CD47 activity； and (ii) an antibody that specifically binds to EGFR. In some embodiments the cancer cells have a mutated form of one or more of KRAS, NRAS or BRAF. The level of depletion of the targeted cell is enhanced relative to a regimen in which a single agent is used； and the effect may be synergistic relative to a regimen in which a single agent is used.
