THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人:
SCHNORR, PETER,CHHABRA, AKANKSHA,SHIZURU, JUDITH A.,WEISSMAN, IRVING L.,WEISKOPF, KIPP ANDREW
申请号：
CA2996167
公开号：
CA2996167A1
申请日:
2016.08.26
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Methods are provided for targeting cells for depletion, including without limitation tumor cells, in a regimen comprising contacting the targeted cells with a combination of agents that modulate immunoregulatory signaling. Immunoregulatory modulating agents include (i) an agent that blockades CD47 activity； and (ii) an agent that agonizes an immune costimulatory molecule, e.g. CD137. The regimen may further comprise an agent that specifically binds to the target cell, e.g. an antibody or biologically active fragment or derivative thereof. The level of depletion of the targeted cell is enhanced relative to a regimen in which a single immunoregulatory modulating agent is used； and the effect may be synergistic relative to a regimen in which a single immunoregulatory modulating agent is used.
