THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人:
WEISSMAN, Irving L.,MCKENNA, Kelly Marie,WILLINGHAM, Stephen,HO, Doris Po Yi,DALERBA, Piero D.,VOLKMER, Jens-Peter
申请号：
USUS2016/065641
公开号：
WO2017/100462A2
申请日:
2016.12.08
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Methods are provided for targeting cells for depletion, including without limitation cancer cells, in a regimen comprising contacting the targeted cells with a combination of agents, including (i) an agent that blockades CD47 activity； and (ii) an antibody that specifically binds to EGFR. In some embodiments the cancer cells have a mutated form of one or more of KRAS, NRAS or BRAF. The level of depletion of the targeted cell is enhanced relative to a regimen in which a single agent is used； and the effect may be synergistic relative to a regimen in which a single agent is used.
