Ledbetter, Jeffrey A.,Hayden-Ledbetter, Martha S.,Thompson, Peter A.,Grosmaire, Laura Sue,Simon, Sandy Alexander
申请号：
AU2012203322
公开号：
AU2012203322A1
申请日:
2012.06.06
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2012203322A120120628.pdf#####ABSTRACT The present invention generally provides methods for B-cell reduction in an individual using CD37-specific binding molecules. In particular, the invention provides methods for B-cell reduction using CD37-specific binding molecules alone, or a combination of CD37-specific binding molecules and CD20-specific binding molecules, in some instances a synergistic combination. The invention further provides materials and methods for treatment of diseases involving aberrant B-cell activity. In addition, the invention provides humanized CD37specific binding molecules.
