abstract the present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, which modulate the activity of janus kinase (jak) and are useful in the treatment of diseases related to the activity of jak including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases. Patent Summary: "Tricyclic fused thiophene derivatives as jak inhibitors". The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, which modulate janus kinase (jak) activity and are useful in the treatment of jak activity-related diseases including, for example, inflammatory disorders, autoimmune disorders , cancer, and other diseases.abstract the present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of janus kinase (jak) and are useful in the treatment of diseases related to the activity of jak including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases. tradução do resumo resumo patente de invenção: "derivados de tiofeno fundidos tricíclicos como inibidores de jak". a presente invenção fornece derivados tiofeno fundidos tricíclicos, bem como suas composições e métodos de uso, que modulam a atividade de janus quinase (jak) e são úteis no tratamento de doenças relacionadas à atividade de jak incluindo, por exemplo, distúrbios inflamatórios, distúrbios autoimunes, câncer, e outras doenças.
