Richard Bethell,Anders Eneroth,Bjorn Klasson,Fredrik Oberg
申请号：
US15506692
公开号：
US10144750B2
申请日:
2015.08.24
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention provides compounds of the formula:R1 is OR11, or NR5R5′；R2 is H or F；R5 is H, OH, C1-C6 alkyl, OH, C(═O)R6, O(C═O)R6 or O(C═O)OR6；R5′ is H or C1-C6 alkyl；R6 is C1-C6 alkyl or C3-C7 cycloalkyl；R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22；and the other variables are as defined in the claims,which are of use in the treatment of cancer, and related aspects.
