Chan Thomas,Ashwell Mark A,Baker Jerome F,Palmer Rocio,Luo Xincai
申请号：
US201615575802
公开号：
US2018121597(A1)
申请日:
2016.05.22
申请国别(地区):
美国
年份:
2018
代理人:
摘要：
The present invention provides SHP2, PTP-PEST (PTPN12, PTPG1), LYP (PTPN22, PEP, PTPN8), PIP1B and STEP Enrichment models, and methods of deriving enrichment models for other tyrosine phosphatases, which function depends on movements of the WPD-loop. Also provided are methods to compare phosphatase Enrichment Models. This provides an implementable process to identify selective modulators of phosphatase activity. Furthermore, it provides methods to select modulators expected to a pre-determined modulators activity across a pre-selected subset of phosphatases. The phosphatase Enrichment Models of the present invention can be used to screen for or design modulators of tyrosine phosphatase function.
