The University of Western Australia;Monash University
发明人:
PFLEGER, Kevin Donald George,THOMAS, Merlin Christopher,PICKERING, Raelene Jane,ROSADO, Carlos,TIKELLIS, Christos
申请号：
AU2018322482
公开号：
AU2018322482A1
申请日:
2018.08.21
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
A method of screening candidate agents for their ability to modulate RAGE activity where such RAGE activity is induced by an active co-located GPCR, the method comprising the steps of: contacting a RAGE polypeptide with a GPCR polypeptide in the presence of a candidate agent where the GPCR polypeptide is constitutively active and/or is activated by addition of an agonist, partial agonist or allosteric modulator of that GPCR； and detecting whether the candidate agent is a modulator of RAGE ligand-independent activation of RAGE by activated co-located GPCR by detecting an effect indicative of modulation of RAGE activation by the presence of the candidate agent and/or by detecting RAGE-dependent signalling that is modulated by the presence of the candidate agent.
