A device (1) for therapeutic treatment of a target, in particular an organ or tissue. The device (1) is operable in at least a detection mode during a detection phase and a treatment mode during a treatment phase. The device comprises a control for operating said device, a HIFU transducer (2) for generating and transmitting ultrasound pulses (6) to said target and at least one component (3) which is sensitive to HIFU, in particular an imaging transducer. In the detection mode, a processor is adapted to generate a harmful condition signal indicating whether or not there is a harmful condition in which reflected HIFU waves (7) would impinge on said sensitive component (3) in such a manner as to transmit an amount of energy/power being harmful for the sensitive component (3). The control is adapted to define operation characteristics of said device (1) for the treatment phase based on the harmful condition signal generated by said processor during the detection phase such that the reflected HIFU waves (7) do not impinge on said component (3) in such a manner as to transmit an amount of energy being harmful for the sensitive component (3) in the treatment phase.
