Apparatus for transcranial imaging comprises an ultrasound source, placed in conjunction with a cranium, producing ultrasound at one or more ultrasound wavelengths that are focused on a location of interest within the cranium. The ultrasound generates RF radiation using the acousto-electric effect and a radio receiver detects the resulting radio frequency radiation emanating from the location of interest. Different types of brain tissue, as well as healthy and diseased tissue, produce different amplitudes of RF radiation, which can be detected as the location of interest is scanned over the volume of the brain, and used to produce an image of the brain.