Substituted indole derivatives and methods of use thereof

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专利权人:

MERCK SHARP & DOHME CORP.

发明人:

ANILKUMAR, GOPINADHAN,BENNETT, FRANK,CHAN, TIN-YAU,CHEN, KEVIN,SANNIGRAHI, MOUSUMI,VELAZQUEZ, FRANCISCO,VENKATRAMAN, SRIKANTH,ZENG, QINGBEI,DUCA, JOSE,LESBURG, CHARLES,KOZLOWSKI, JOSEPH,NJOROGE, F.,RO

申请号：

ES08795629

公开号：

ES2447543T3

申请日:

2008.08.27

申请国别(地区):

ES

年份:

2014

代理人:

摘要：

A compound having the formula (I): ** Formula ** or a pharmaceutically acceptable salt or solvate thereof, wherein: R1 is -CH2-, -CH2CH2-, -CH (CH3) - or ** Formula ** R2 is -C (O) OH. R3 is: ** Formula ** R4, R5, R6 and R7 are each, independently, H, alkyl, - [C (R12) 2] q-cycloalkyl, - [C (R12) 2] q-heterocycloalkyl, haloalkyl , halo, -OH, -OR9 or -N (R9) 2； each time R9 appears it is independently H, alkyl, cycloalkyl, heterocycloalkyl, haloalkyl ohydroxyalkyl； R10 is: ** Formula **Un compuesto que tiene la fórmula (I):**Fórmula** o una sal o un solvato del mismo farmacéuticamente aceptables, en la que: R1 es -CH2-, -CH2CH2-, -CH(CH3)- o**Fórmula** R2 es -C(O)OH. R3 es:**Fórmula** R4, R5, R6 y R7 son cada uno, independientemente, H, alquilo, -[C(R12)2]q-cicloalquilo, -[C(R12)2]q-heterocicloalquilo,haloalquilo, halo, -OH, -OR9 o -N(R9)2； cada vez que aparece R9 es independientemente H, alquilo, cicloalquilo, heterocicloalquilo, haloalquilo ohidroxialquilo； R10 es:**Fórmula**

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