The Kingdom Of The Netherlands; Represented By The Minister of Health; Welfare and Sport
发明人:
Oloo, Eliud,Comen, Raymond,Ochs, Martina,Yethon, Jeremy
申请号：
AU2013204613
公开号：
AU2013204613A1
申请日:
2013.04.12
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2013204613A120130516.pdf#####Abstract Modified steptococcus pneumonia pneumolysin (ply) polypeptides This disclosure relates to modified Streptococcus pneumonia pneumolysm (PLY) proteins which lack hemolytic activity and can be used as immunogens in an immunogenic composition or vaccine against invasive pneumococcal diseases caused by S. pneumonia The modified pneumolysm proteins comprise ammo acid substitutions at threonine 65, glycine 293 and cysteine 428 Nucleic acids, polypeptides encoded thereby, compositions containing the same, methods for using such nucleic acids, polypeptides and compositions are also provided
