KINGDOM OF THE NETHERLANDS; REPRESENTED BY THE MIN ISTER OF HEALTH; WELFARE & SPORT; ON BEHALF OF THE MINISTER; NAT.INST. OF PUBLIC HEALTH & THE ENV.
发明人:
OLOO, ELIUD,OOMEN, RAYMOND,OCHS-ONOLEMHEMHEN, MARTINA,YETHON, JEREMY
申请号：
EP09833971
公开号：
EP2376526A4
申请日:
2009.12.22
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
This disclosure relates to modified Streptococcus pneumonia pneumolysm (PLY) proteins which lack hemolytic activity and can be used as immunogens in an immunogenic composition or vaccine against invasive pneumococcol diseases caused by S. pneumonia. The modified pneumolysm proteins comprise ammo acid substitutions at threonine 65, glycine 293 and cysteine 428 Nucleic acids, polypeptides encoded thereby, compositions containing the same, methods for using such nucleic acids, polypeptides and compositions are also provided.
