JEREMY YETHON,MARTINA OCHS,ELIUD OLOO,RAYMOND COMEN
申请号：
IL21373411
公开号：
IL213734A
申请日:
2011.06.22
申请国别(地区):
IL
年份:
2017
代理人:
摘要：
This disclosure relates to modified pneumolysm (PLY) proteins which lack hemolytic activity and can be used as immunogens in an immunogenic composition or vaccine against invasive pneumococcol diseases caused by The modified pneumolysm proteins comprise ammo acid substitutions at threonine 65, glycine 293 and cysteine 428 Nucleic acids, polypeptides encoded thereby, compositions containing the same, methods for using such nucleic acids, polypeptides and compositions are also provided
