THE KINGDOM OF THE NETHERLANDS ; REPRESENTED BY THE MINITER OF HEALTH ; WELFARE AND SPORT; ON BEHALF OF THE MINISTER ; THE NATIONAL INSTITUTE OF PUBLIC HEALTH AND THE ENVIRONMENT
发明人:
OLOO ELIUD,OCHS-ONOLEMHEMHEN MARTINA,OOMEN RAYMOND,YETHON JEREMY
申请号：
ZA201104627
公开号：
ZA201104627B
申请日:
2011.06.22
申请国别(地区):
ZA
年份:
2012
代理人:
摘要：
This disclosure relates to modified Streptococcus pneumonia pneumolysm (PLY) proteins which lack hemolytic activity and can be used as immunogens in an immunogenic composition or vaccine against invasive pneumococcol diseases caused by S. pneumonia. The modified pneumolysm proteins comprise ammo acid substitutions at threonine 65, glycine 293 and cysteine 428 Nucleic acids, polypeptides encoded thereby, compositions containing the same, methods for using such nucleic acids, polypeptides and compositions are also provided.
