Claim 1: a compound calculated according to formula (1),Or one of the acceptable salts: R1 es conrr, CN or c-833183323；where each alkyl is optionally substituted with C₁₋₃ alkoxy,-OH, -CN, -NRR or -CONRR； R² and R³ are independently selected from H, halo, -CN, C₁₋₆ alkyl,C₂₋₆ alkenyl,1. C 83228331 asphalt；C₃₋₆ cycloalkyl,C₁₋₆ alkoxy,-CONRR or C (O) ₂R； wherein the alkyl, alkenyl, cycloalkyl and alkoxy represented by R² or R³ are independently and optionally substituted with one or more halo, -CN, -OH, C₁₋₃ alkyl,Halogenated tar c83218323；C₃₋₆ cycloalkyl,C₁₋₃ alkoxy,hello Coxi C₁₋₃,-NRR, the out of phase period of 5-7 members, - C (o) NRR o-nrc (o) r； each R and R are independently selected between hydrogen, c83218c and 833226a；C₃₋₆ cycloalkyl,1. Phenyl, isopropyl of 5 to 6 members or isopropyl of 5 to 6 members； in these substances, each tar, cyclopropyl, phenyl, isopropyl and isopropyl is optional and replaced with one or more halogens；Halogenated tar c83218323；C₃₋₆ cycloalkyl,C₁₋₃ alkoxy,hello Coxi C₁₋₃,-C (O) alquilo C-C (O) alcoxi C-NH832222,-NH asphalt c8321c8331；-N (alquilo C)1.5-7 member's heterocycle or 5-7 member's heterocycle； but R2 and R3 are different hydrogen； and R1 sea-c (o) NRR, there is no R2 or R3 sea-c (o) NRR.Reivindicación 1: Un compuesto de acuerdo con la fórmula (1), o una de sus sales farmacéuticamente aceptables, donde: R¹ es -CONRR, -CN o alquilo C₁₋₃, donde cada alquilo está opcionalmente sustituido con alcoxi C₁₋₃, -OH, -CN, -NRR o -CONRR； R² y R³ se seleccionan independientemente entre H, halo, -CN, alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, cicloalquilo C₃₋₆, alcoxi C₁₋₆, -CONRR o C(O)₂R； donde el alquilo, alquenilo, cicloalquilo y alcoxi representados por R² o R³ están independiente y opcionalmente sustituidos con uno o más halo, -CN, -OH, alquilo C₁₋₃, haloalquilo C₁₋₃, cicloalquilo C₃₋₆, alcoxi C₁₋₃, haloalcoxi C₁₋₃, -NRR, heterociclo de 5 - 7 miembros, -C(O)NRR o -NRC(O)R； y cada R y R se selecciona independientemente entre hi
