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Tetracyclic cysteine protease inhibitors, their pharmaceutical compositions and their therapeutic applications
专利权人:
HYBRIGENICS S.A.
发明人:
GUEDAT, Philippe,JACQ, Xavier,COLLAND, Frédéric,DAVIET, Laurent,FORMSTECHER, Etienne,RAIN, Jean-Christophe,COLOMBO, Matteo
申请号:
ES07848828
公开号:
ES2633095T3
申请日:
2007.10.25
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Compound of formula (I): ** Formula ** in which: ---- is a single bond or a double bond, as appropriate; ---- is none or a single link, as the case may be; ** Formula ** U, V, W are the same or different and can be selected from C, N, O, S, Y is N-OR1, NR ' one; R1 is H, alkyl, alkenyl, alkoxyalkyl, aryloxyalkyl, arylalkyl, alkoxycarbonylalkyl, carboxyalkyl; R'1 is H, alkyl, aryl or aralkyl; R2, R2 are each the same or different and are independently selected from H, alkyl, aryl or aralkyl; Rv, Rw are the same or different and can be selected from the group consisting of H, CN,>; = O, Hal, Alq, OAlq, OH, NRCN, C (CN)>; = C (OH) (OAlq), SR, NRR ', C (O) NRR', heterocycle, aryl, heteroaryl, cycloalkyl, in which Alq, Aryl, heteroaryl, heterocycle, cycloalkyl are optionally substituted by Hal, NRR ', CN, OH, CF3, aryl, heteroaryl, OAlq ; Ru is selected from H, Alq, NRR ', OAlq; R3, R4, R5, R6 are each the same or different and are independently selected from the group consisting of H, OAlq, Alq, Hal, OCF3; R and R 'are each the same or different and are independently selected from the group consisting of H, Alq, in which Alq is optionally substituted by Hal, NRR', CN, OH, CF3, aryl, heteroaryl; or its pharmaceutically acceptable salts, hydrates, or hydrated salts, or its optical isomers, racemates, diastereomers or enantiomers, or its regioisomers, geometric isomers (E and Z) or mixtures thereofCompuesto de fórmula (I):**Fórmula** en la que: ---- es un enlace sencillo o un doble enlace, según el caso; ---- es ninguno o un enlace sencillo, según el caso;**Fórmula** U, V, W son iguales o diferentes y se pueden seleccionar entre C, N, O, S, Y es N-OR1, NR'1; R1 es H, alquilo, alquenilo, alcoxialquilo, ariloxialquilo, arilalquilo, alcoxicarbonilalquilo, carboxialquilo; R'1 es H, alquilo, arilo o aralquilo; R2, R'2 son cada uno iguales o diferentes y se seleccionan independientemente entre H, alquilo, arilo o aralquilo; Rv, Rw son iguales o diferentes y se pueden selecci
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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