GILIYAR, CHANDRASHEKAR,VENKATESHWARAN, SRINIVANSAN,CHICKMATH, BASAWARAJ,NACHAEGARI, SATISH KUMAR,NACHIAPPAN, CHIDAMBARAM,PATEL, MAHESH V.
申请号：
CA2879401
公开号：
CA2879401A1
申请日:
2012.07.27
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The present invention provides for bioavailable oral dosage forms containing esters of 17-hydroxyprogesterone as well as related methods. The oral dosage forms can be formulated for pregnancy support and can include a therapeutically effective amount of an ester of 17-hydroxyprogesterone and a pharmaceutically acceptable carrier. In another embodiment, a pharmaceutically acceptable oral dosage form for pregnancy support is provided. The pharmaceutically acceptable oral dosage can include a therapeutically effective amount of an ester of 17-hydroxyprogesterone and a pharmaceutically acceptable carrier. The oral dosage form can, when measured using a USP Type-II dissolution apparatus in 900 mL of deionized water with 0.5 (w/v) of sodium lauryl sulfate at 50 RPM at 37C, release at least 20 wt% of the dose of the ester of 17-hydroxyprogesterone after 60 minutes, or in the alternative release at least 20 wt% more after 60 minutes than an equivalently dosed oral dosage form without the carrier.
