MOREAU, BENOIT,WHITE, BRIAN H.,BILODEAU, MARK T.,SIMCOX, MARY,WHALEN, KERRY,ALLAND, LEILA,WOOSTER, RICHARD,SHINDE, RAJESH R.
申请号：
CA3045041
公开号：
CA3045041A1
申请日:
2017.12.14
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Conjugates of an active agent attached to a targeting moiety, such as an HSP90 binding moiety, via a linker, and particles comprising such conjugates have been designed. Such conjugates and particles can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer.
