Benoît Moreau,Brian H. White,Mark T. Bilodeau,Mary Simcox,Kerry Whalen,Leila Alland,Richard Wooster,Rajesh R. Shinde
申请号：
US16469768
公开号：
US20200085960A1
申请日:
2017.12.14
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Conjugates of an active agent attached to a targeting moiety, such as an HSP90 binding moiety, via a linker, and particles comprising such conjugates have been designed. Such conjugates and particles can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer.
