BILODEAU, MARK T.,MOREAU, BENOIT,KADIYALA, SUDHAKAR,WOOSTER, RICHARD,WHITE, BRIAN H.
申请号：
CA3094719
公开号：
CA3094719A1
申请日:
2019.04.03
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Conjugates of an active agent attached to a targeting moiety, such as at least one HSP90 binding moiety, via a linker, have been designed. Such conjugates can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer.
