CIPRIANI, TYLER,MOREAU, BENOIT,BILODEAU, MARK T.,QUINN, JAMES M.,WOOSTER, RICHARD,CIRELLO, AMANDA L.,PERINO, SAMANTHA,WHALEN, KERRY,KADIYALA, SUDHAKAR,WHITE, BRIAN H.
申请号：
CA3085759
公开号：
CA3085759A1
申请日:
2018.12.14
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Conjugates of an active agent attached to a targeting moiety, such as an HSP90 binding moiety, via a linker, and particles comprising such conjugates have been designed. Such conjugates and particles can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer.
